I have a minor sideline in the prognostication of future events. Normally, I confine myself to US presidential and papal elections (the last two of which I got right -- I even successfully predicted what the new Pope's regnal name would be), but this is a gaming blog, so I think I should confine myself here to gaming predictions.
Fortunately, I have one and it's this: Dungeons & Dragons, Fourth Edition, will not be an open game -- at least not in the usual sense of "open." The mysterious GSL (né OGL 2.0) has still not appeared and my guess is that it never will. Much more likely is that WotC will partner with a small number of select third party publishers (such as Necromancer and Goodman Games), granting them limited use trademark licenses. Heck, WotC might even call the license they grant to such companies the GSL to save face. They'll almost certainly come out with a press release saying that they're "working with the finest companies in the gaming industry to produce the best 4e support products imaginable." But there will not be an open game license for 4e that anybody can use to make their own 4e-compatible product.
Now that I've said it here, feel free to laugh and make fun of me when it turns out I'm wrong. I don't think I will be, though. The reality is that the guys at WotC who pioneered open gaming and who really believed in it are long gone. Their successors possess neither the zeal for nor the understanding of why the OGL/D20 STL was so successful and so official support for that movement will die. I've said it elsewhere but it bears repeating: the advent of 4e is not so much about making a better D&D -- though I don't doubt that its designers firmly believe that's what they're doing -- as about shoring up the value and profitability of the D&D trademark and IP. By bean-counting metrics, D&D is hugely under-performing compared to similarly well-known IPs and 4e is intended to fix that, which is why 4e won't be "giving the store away for free" this time around.